Antipsychotic Medication’s Effects on Sleep Apnea and Driving Performance

Recent research highlights the potential benefits and risks of using quetiapine, a commonly prescribed antipsychotic, for treating obstructive sleep apnea (OSA). A study conducted by researchers at Flinders University in Adelaide, Australia, explored its effects on sleep and driving performance.

Study Overview

This small, randomized controlled trial involved 15 adults diagnosed with OSA, also experiencing difficulties in maintaining sleep. Participants underwent two overnight studies a week apart, examining the impacts of quetiapine and a placebo.

During the research, participants received 50mg of quetiapine before sleeping on one occasion, and a placebo on another night. Quetiapine, known for treating schizophrenia, bipolar disorder, and depression, is often prescribed off-label for insomnia and anxiety.

Findings on Sleep Improvement

Data showed participants taking quetiapine experienced over 40 minutes of additional sleep and a 45% reduction in night wakefulness. Their apnea-related incidents decreased from 27 to 20 events per hour.

Concerns Regarding Driving Performance

Despite the sleep benefits, quetiapine slowed reaction times in driving simulations compared to the placebo. Tests conducted within 30 minutes of waking indicated a significant increase in attention lapses and lane deviation among quetiapine users.

Participants reported feeling sleepier after quetiapine use, with some unaware of their impaired driving abilities. Mild to moderate side effects, such as nausea and restless legs, were noted. Around one in three reported a sudden drop in blood pressure when standing.

Recommendations and Considerations

Researchers emphasize that larger, long-term studies are necessary to validate these results before recommending quetiapine for sleep disorders. Until further research, avoiding driving or safety-critical activities for at least 9.5 hours post-quetiapine is advised.

Expert Ashley Curtis from the University of South Florida highlights the importance of understanding sex differences in drug metabolism. Women generally metabolize such medications more slowly, influencing both efficacy and the risk of side effects.

“Future studies should carefully examine whether these newer agents demonstrate similar sex-specific patterns to ensure optimal dosing and safety recommendations,” Curtis noted.

Implications for Older Adults

Given the vulnerability of older adults to cognitive side effects from polypharmacy, balancing sleep benefits and daytime functioning requires careful consideration.

Research suggests incorporating cognitive-behavioral therapy with medication offers strong long-term management for insomnia.

Chelsie Rohrscheib, a sleep expert from Wesper, advises patients using quetiapine for sleep-related issues to consult their doctors about the medication’s risks and alternative treatments.

Fox News Digital has reached out to the drug manufacturer and study researchers for additional comments.